Cadmium is a mutagen that acts by inhibiting mismatch repair
نویسندگان
چکیده
منابع مشابه
MutSα maintains the mismatch repair capability by inhibiting PCNA unloading
Eukaryotic mismatch repair (MMR) utilizes single-strand breaks as signals to target the strand to be repaired. DNA-bound PCNA is also presumed to direct MMR. The MMR capability must be limited to a post-replicative temporal window during which the signals are available. However, both identity of the signal(s) involved in the retention of this temporal window and the mechanism that maintains the...
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Cadmium (Cd2+) is a known carcinogen that inactivates the DNA mismatch repair (MMR) pathway. In this study, we have tested the effect of Cd2+ exposure on the enzymatic activity of the mismatch binding complex MSH2-MSH6. Our results indicate that Cd2+ is highly inhibitory to the ATP binding and hydrolysis activities of MSH2-MSH6, and less inhibitory to its DNA mismatch binding activity. The inhi...
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This article presents an argument for the existence of God, showing that the evident phenomena are best explained by supposing that a God causes them. The argument is based on the inductive force of four very evident general phenomena: that there is a physical Universe; that it is governed by very simple natural laws; that those laws are such as to lead to the existence of human bodies; and tha...
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متن کاملSpontaneous mutation at a 5-methylcytosine hotspot is prevented by very short patch (VSP) mismatch repair.
In many strains of Escherichia coli, the product of gene dcm methylates the internal cytosines in the sequence 5'CC(A or T)GG. Spontaneous deamination of 5-methylcytosine produces thymine which, if not corrected, can result in a transition mutation. 5-Methylcytosines in the lacI gene are hotspots for spontaneous C to T mutations. dcm is linked to vsr, a gene required for very short patch (VSP) ...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2003
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1172